王彦卿,男,博士,教授,中国化学会高级会员,盐城市化学化工学会理事长,现任盐城师范学院化学与环境工程学院院长,2001年获曲阜师范大学理学学士学位,2004年获贵州大学理学硕士学位, 2011年获南京大学理学博士学位,2014年2月-2015年2月在英国Warwick大学化学系访学,南京工业大学兼职硕士生导师,江苏省“青蓝工程”中青年学术带头人,江苏省“333工程”高层次人才培养对象,江苏省“青蓝工程”优秀青年骨干教师,江苏省高校优秀中青年骨干教师境外研修人员,盐城市第五届“十佳科技标兵”,盐城师范学院中青年学术带头人,入选2022年“全球顶尖前10万科学家排名”榜单。主持国家自然科学基金面上项目2项,其中完成1项,江苏省自然科学基金面上项目2项。以第一作者或通讯联系人在《Nano Research》《Carbohydrate Polymers》《Carbon》《Journal of Inorganic Biochemistry》《Journal of Hazardous Materials》《Journal of Agricultural and Food Chemistry》等国内外SCI收录期刊上发表论文120多篇,所发表文章被引用次数达2800多次, h-index系数为27。
承担的教学课程:
物理化学选讲、生物化学、药物分析、精细化学品化学、基础化学实验III等
研究方向:
1. 新型金属抗癌药物的设计及其作用机制研究
2. 毒物及药物小分子与蛋白质作用机理研究
3. 纳米抗癌药物载体材料的设计及组装机理研究
科研成果:
主要科研项目:
1.“光响应性四价铂前药—多糖微凝胶的构筑及其光动力和免疫协同抗肿瘤研究(22172138)”,国家自然科学基金(面上项目),2022.1-2025.12,60万元。
2. “铂、钌类金属抗癌药物与血浆蛋白相互作用对蛋白功能和性质的影响及机理研究(21571154)”,国家自然科学基金(面上项目),2016.1-2017.12,35万元。
3.“肿瘤铂配合物影响硫氧还蛋白还原酶结构及活性的研究(BK2012671)”,江苏省自然科学基金(面上项目),2013.6-2015.6,10万元。
4.“新型铂类金属抗癌药物与血清蛋白作用机理研究(BK2016022134)”,江苏省自然科学基金(面上项目),2016.6-2019.6,10万元。
科研论文代表作:
1. Q. Luo, Q. Han, L. Chen, X. Fan, Y. Wang, Z. Fei*, H.M. Zhang*, Y.Q. Wang*, Redox response, antibacterial and drug package capacities of chitosan-α-lipoic acid conjugates, International Journal of Biological Macromolecules, 2020,154:1166.
2. Y. Wang, Q.Q. Han, F. Bai, Q. Luo, M. Wu, G. Song, H.M. Zhang*, Y.Q. Wang*, The assembly and antitumor activity of lycium barbarum polysaccharide platinum-based conjugates, Journal of Inorganic Biochemistry, 2020,205:111001.
3. Q. Luo, Y. Wang, Q. Han, L. Ji, H.M. Zhang, Z. Fei*, Y.Q. Wang*, Comparison of the physicochemical, rheological, and morphologic properties of chitosan from four insects, Carbohydrate Polymers, 2019,209:266.
4. F. Bai, Y. Wang, Q.Q. Han, M. Wu, Q. Luo, H.M. Zhang*, Y.Q. Wang*, Cross-linking of hyaluronic acid by curcumin analogue to construct nanomicelles for delivering anticancer drug, Journal of Molecular Liquids, 2019,288:111079.
5. H.M. Zhang, Z. Zhu, Y.Q. Wang*, Z. Fei, J. Cao, Changing the activities and structures of bovine serum albumin bound to graphene oxide, Applied Surface Science, 2018,427:1019.
6. H.M. Zhang, M. Zhang, Y. Wang, Y.Q. Wang*, S. Sun, Z. Fei, J. Cao*, Effects of selected two noble metal ions in medicine on the structure and activity of bovine serum albumin: A multi-spectral studies, Journal of Luminescence, 2018,184:519.
7.Z.H. Zhu, Y.Q. Wang*, Y. Kang, H.M. Zhang, Z. Zhang, Z. Fei, J. Cao,Graphene oxide destabilizes myoglobin and alters its conformation, Carbon, 2017,114:449.
8.F. Bai, J. Diao, Y. Wang, S. Sun, H. Zhang, Y. Liu, Y.Q. Wang*, J. Cao, A new water-soluble nanomicelle formed through self-assembly of pectin−curcumin conjugates: Preparation, characterization, and anticancer activity evaluation, Journal of Agricultural and Food Chemistry, 2017, 65:6840.
9. Y.Q. Wang, Anaïs Pitto-Barry, Abraha Habtemariam, Isolda Romero-Canelon, Peter J. Sadler* , Nicolas P. E. Barry*, Nanoparticles of chitosan conjugated to organoruthenium complexes, Inorganic Chemistry Frontiers, 2016, DOI: 10.1039/C6QI00115G
10. Y.Q.Wang*,H.M. Zhang,Y.J. Kang, Z.H. Fei, J. Cao*, The interaction of perfluorooctane sulfonate with hemoglobin: Influence on protein stability, Chemico-Biological Interactions 2016, 254: 1.
11. Y.Q. Wang*, H.M. Zhang, Exploration of binding of bisphenol A and its analogues with calf thymus DNA by optical spectroscopic and molecular docking methods, Journal of Photochemistry and Photobiology B: Biology 2015,149: 9.
12.H.M. Zhang, K. Lou, J. Cao*, Y.Q. Wang*, Interaction of a hydrophobic- functionalized PAMAM dendrimer with bovine serum albumin: thermodynamic and structural changes. Langmuir, 2014, 30: 5536.
13.Y.Q.Wang*,H.M. Zhang,Effects of bisphenol s on the structures and activities of trypsin and pepsin, Journal of Agricultural and Food Chemistry, 2014, 62: 11303.
14.Y.Q.Wang*, C.Y. Tang, S.L. Zhuang, P.Z. Zhai, Y. Cui, Q.H. Zhou, H.M. Zhang, Z.H. Fei, In vitro and in silico investigations of the binding interactions between chlorophenols and trypsin, Journal of Hazardous Materials, 2014, 278: 55.
15.Y.Q.Wang*,H.M. Zhang, Comparative Studies of the Binding of Six Phthalate Plasticizers to Pepsin by Multispectroscopic Approach and Molecular Modeling, Journal of Agricultural and Food Chemistry, 2013, 61:11191.
16.Y.Q.Wang,J. Wang, X.Y. Wang, W.J. He, Z.J. Guo, Noncovalent interactions between a trinuclear monofunctional platinum complex and human serum albumin, Inorganic Chemistry, 2011, 50:11661.
主要专利:
1. 王彦卿, 王莹, 孙世新, 韩倩倩, 张红梅, 费正皓, 一类枸杞多糖修饰的纳米粒子制备及其抗肿瘤活性研究, 申请专利号:201910321062.5.
2. 王彦卿, 王莹, 孙世新, 韩倩倩, 张红梅, 费正皓, 一种多糖药物复合纳米粒子的制备及其抗肿瘤活性研究, 申请专利号: 201910321063.X.
3. 王彦卿, 罗强, 孙世新, 王莹, 张红梅, 费正皓, 一种水溶性硫醇化壳聚糖的制备方法和应用, 申请专利号:201910321066.3.
4. 王彦卿,韩倩倩,孙世新,张红梅,马齿苋多糖与顺铂复合物的制备及其协同抗肿瘤活性研究,申请专利号:202010701572.8.
联系方式:
E-mail:wyqing76@126.com